Multidimensional Exploration into Biochemical Pathways
نویسندگان
چکیده
The famous Biochemical Pathways wall chart has been converted into a reaction database. The web based retrieval system C@ROL has been interfaced to this BioPath database providing a wide variety of search methods for chemical structures, enzymes, and reactions that can allow one to explore the endogenous metabolism of different species. The database has been made accessible on the internet at: http://www2.chemie.uni-erlangen.de/services/biopath/index.html and http://www.mol-net.de/databases/biopath.html. It is shown how the information in this database can be used to explore enzyme inhibitors as transition state mimics. Furthermore, it is shown how the classification of biochemical reactions based on physicochemical effects at the reaction site, corresponds with the classification of enzymes by the EC code.
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